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Background
NACET (N-Acetyl-L-Cysteine Ethyl Ester) is an analog derivative of NAC (N-Acetyl-L-Cysteine), an endogenous antioxidant compound[1] with a wide range of therapeutic effects and biological significance. Esterification of NAC allows the molecule to permeate cells, delivering NAC and Cysteine, thus greatly enhancing the bioavailability and potential of the compound.[2] The antioxidant effects of NAC are owed both to its structure and synthesis of glutathione from Cysteine. NAC’s significance of mental health is partially due to its ability to inhibit the release of glutamate, in some clinical trials showing improvements to schizophrenia,[3] OCD,[4] bipolar disorder[5] and more. The protective effect of NAC is demonstrated most applicably with hepatotoxicity and neurotoxicity, although its use is broad in clinical contexts. We hope to encourage research by allowing researchers to buy NACET.
NACET was created after the failure of NAC in clinical studies evaluating stress.[2]
References
[1] Quantifying endogenous NAC: https://onlinelibrary.wiley.com/doi/abs/10.1002/bdd.2510120504
[2] Enhanced bioavailability of NACET: https://pubmed.ncbi.nlm.nih.gov/23000913/
[3] NAC for Schizophrenia: https://link.springer.com/article/10.2165/11586650-000000000-00000
[4] NAC for OCD: https://pubmed.ncbi.nlm.nih.gov/29908912/
[5] NAC for bipolar disorder: https://www.nature.com/articles/s41398-021-01727-7
Disclaimer
Scientific discussion is purely for educational purposes. This is not medical advice.
