MK-677 – Solution (25mg/mL)


✓ High quality reference material

✓ Approximately 25mg per 1mL

✓ Contains 30mL per bottle (750mg MK-677)

✓ Estimated 30-90 days of research supply

This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

74 in stock

Buy MK-677 | HGH increasing ghrelin agonist | Read more:


Ibutamoren (MK-677) was designed to treat growth hormone deficiencies which may occur during childhood or as an elder. A deficiency of this hormone results in frailness and/ or stunted growth. By acting as a ghrelin mimetic, Ibutamoren stimulates both appetite and muscle fiber synthesis, normally resulting in weight gain by subjects given it. Additionally human growth hormone has been shown on numerous occasions to improve wound healing. We hope to encourage research by allowing researchers to buy MK-677.


Ibutamoren (MK-677) is a potent, long-acting, orally-active, selective small molecule agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone-stimulating action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones.

The effect of MK-677 on prolactin is variable, with adolescents experiencing no change[1] and elders experiencing a 27% increase.[2] The same inconsistency is shown with cortisol, wherein one study shows an increase[3] and another shows no change.[4]


[1] MK-677 does not increase prolactin in children:

[2] MK-677 does increase prolactin in elders:

[3] MK-677 increases cortisol:

[4] MK-677 does not increase cortisol:

ApplicationGhrelin mimetic
Molar Mass528.662 g/mol
Chemical FormulaC27H36N4O5S
IUPAC Name2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide; methanesulfonic acid
SynonymsIbutamoren, MK-677, MK-0677, MK677, L-163,191, L163191, Nutrobal
StorageStore at room temperature, tightly sealed, away from heat, light and moisture.
SolubilitySoluble in Propylene Glycol, PEG400
Organoleptic ProfileClear liquid
Physical FormLiquid, solved in Propylene Glycol
Specification25mg/mL±10% in 30mL, purity 97.1%+. Chemical analysis available on request.