Carnosic Acid – Powder (10g, 95% Extract)

$34.99

✓ High quality reference material

✓ Contains 10g per jar

✓ Around ~500mg per 1/4 teaspoon scoop

✓ Estimated 40 days of research supply

Application Anxiolytic
CAS 3650-09-7
Molar Mass 332.4 g/mol
Chemical Formula C20H28O4
IUPAC Name (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
Synonyms Carnosic Acid, Salvin, LI791SXT24, Deoxypicrosalvinic acid, 11,12-dihydroxyabieta-8,11,13-trien-20-oic acid
Storage Store at room temperature, tightly sealed, away from heat, light and moisture.
Solubility Soluble in ethanol, DMSO, and dimethyl formamide
Organoleptic Profile Green opaque powder
Physical Form Powder
Specification Purity 95%+. Chemical analysis available on request.
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

55 in stock (can be backordered)

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Background

Carnosic acid is a common constituent of dietary herbs such as rosemary, however this is an extraction of near complete purity (95%).  In some parts of the world, such as China, Carnosic acid is used as a food preservative due to being one of the strongest antioxidants found in nature. It has been shown to preserve fatty acids better than some synthetic antioxidants in studies, suggesting a potent contact antioxidant effect [2]. This correlates with the benefits of rosemary extract to balding when used as a topical treatment [3].

That being said, Carnosic acid has been investigated due to its ability to produce an anxiolytic effect in preclinical trials, by reducing noradrenaline and increasing serotonin [1]. In this study, it reached similar significance in this ability as a synthetic benzodiazepine. That is a surprising finding, for a compound that has no effect on GABA or GABA receptors.

Carnosic acid has also been studied for its beneficial effects in preclinical models of post-traumatic brain injury (TBI) [4], reversing superbug antibiotic resistance (despite having no antibiotic effect on its own) [5], and improving a variety of cognitive impairments from long COVID-19, Alzheimer’s and Parkinson’s [6] in rodents. There are other studies as well, such as in C. Elegans where carnosic acid extended lifespan [7], or other rodent studies where carnosic acid produced anti-diabetic effects such as reducing insulin resistance caused by fatty acids [8], prevented heavy metal toxicity from Cadmium [9]

Pharmacology

 

References

[1] Carnosic Acid anxiolytic effect in rodents: https://www.semanticscholar.org/paper/Key-Role-of-Carnosic-Acid-in-the-Anxiolytic-like-of-Kumar-Agarwal/a5bdfeeb3f9de7617d8216b2f3c5e469425d817a

[2] Carnosic Acid’s preservative effect compared to other antioxidants: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884750/

[3] Rosemary’s effect on balding: https://pubmed.ncbi.nlm.nih.gov/25842469/

[4] Carnosic Acid improves post-TBI cognition in rodents: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602106/

[5] Carnosic Acid reverses antibiotic resistance in rodents: https://www.frontiersin.org/articles/10.3389/fphar.2020.581001/full

[6] Carnosic Acid improves long COVID, Alzheimer’s and Parkinson’s in rodents: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772720/

[7] Carnosic Acid’s effect on lifespan in C. Elegans: https://pubmed.ncbi.nlm.nih.gov/30758000/

[8] Carnosic Acid reduces insulin resistance in rodents: https://www.mdpi.com/2073-4409/11/1/167

[9] Carnosic Acid reverses Cadmium-induced damage in rodents: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891359/

[10] Carnosic Acid

Disclaimer

Scientific discussion is purely for educational purposes. This is not medical advice.

Additional information

Weight 0.045 kg
Dimensions 5.7 × 5.7 × 5 cm