| Class | AMPA receptor positive allosteric modulator |
|---|---|
| CAS | 1358751-06-0 |
| Molar Mass | 373.5 g/mol |
| Chemical Formula | C19H23N3O3S |
| IUPAC Name | 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide |
| Synonyms | TAK-653, TAK653, UNII-9E3TOE5RIZ |
| Storage | Store at room temperature, tightly sealed, away from heat, light and moisture. |
| Solubility | Soluble in Polyethylene Glycol-(200, 300, 400) |
| Organoleptic Profile | Clear liquid |
| Physical Form | Liquid, solved in Polyethylene Glycol-400 |
| Specification | 4mg/mL±10% in 15mL, purity 98.7%+ |
TAK-653 – Solution (4mg/mL)
$27.99
✓ High quality reference material
✓ Approximately 2mg per 0.5mL
✓ Contains 15mL per bottle (60mg TAK-653)
89 in stock (can be backordered)
Background
TAK-653 is a highly selective positive allosteric modulator of AMPA receptors (AMPA PAM) with minimal intrinsic agonist activity [1]. It has been evaluated in Phase 1 clinical studies [2].
Pharmacology
TAK-653 binds the allosteric site of the AMPA receptor and potentiates glutamate-evoked responses. In preclinical studies this increased BDNF release in the hippocampus [3].
References
[1] https://www.nature.com/articles/s41598-021-93888-0
[2] https://pubmed.ncbi.nlm.nih.gov/36153330/
[3] https://www.sciencedirect.com/science/article/pii/S009130572100188X
Research use only
For laboratory research use only. Not for human or animal consumption, or for any medical, diagnostic, therapeutic or recreational use.
